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“There is reason to believe that histamine is the primary vasodilator contributing to post-exercise hypotension, but we cannot say for certain,” cautioned principal investigator John R. Halliwill, a professor of human physiology. “Some people have problems regulating blood pressure during and after exercise. Trained athletes have had fainting bouts at the end of exercise. It may be that these result from a natural overactivation of these two receptors for histamine.”
The histamine receptors involved are known as H1 and H2. Fexofenadine, which is the generic name for Allegra, works against H1, reducing the occurrence of such allergy symptoms as sneezing and runny nose. Ranitidine, or Zantac, acts against H2 in the treatment of acid reflux.
For the study, 28 sedentary and endurance-trained men and women were monitored closely throughout a session that covered a pre-exercise period, a 60-minute ride on a cycling machine and a 90-minute recovery period. The participants were all non-smokers without blood pressure problems and between the ages of 19 and 34. The group given the histamine blockers consumed them with water 60 minutes before beginning the exercise regimen.
The studies in Halliwill’s Exercise and Environmental Physiology Laboratories were designed to pursue the mechanisms involved in the exercise recovery period. The findings that the two antihistamine products worked as they did do not mean that athletes or sedentary-turned-active people should head to their medicine cabinets before exercising.
The amount of fexofenadine used in the study was almost three times the strongest dose used for respiratory allergies, while the dosage for ranitidine matched the common starting dose for battling heartburn. Also, there may be a benefit to the normal activation of these receptors during physical activity, because routine exercise helps to reduce or prevent the development of hypertension, or high blood pressure. “Activating these receptors might be an important part of the health benefits of daily exercise,” Halliwill said.
The two drugs, however, did not appear to affect the central nervous system or cause sedation during the exercise experiments, Halliwill and co-author Jennifer L. McCord, a doctoral student, noted in the study.
The big question now, Halliwill said, is what triggers the histamine responses during exercise.
“The body tends to be very good at recycling mechanisms,” he said. “The body may be using these same receptors for other things. A bout of exercise appears to turn on a program for remodeling blood vessels in the body, and these receptors may be an important part of that program.”
Overactivation of two receptors for histamine, normally associated with common allergies and acid reflux, may explain why some people, including highly trained athletes, pass out soon after heightened physical activities, according to researchers at the University of Oregon.
A series of studies led researchers in incremental steps to the discovery that the use of two commonly used antihistamines (fexofenadine and ranitidine) prior to exercise dramatically lower or completely eliminate low blood pressure following exertion. The drugs worked by preventing post-exercise hyperemia, an increased flow of blood, in the skeletal muscle during the critical 90-minute recovery period after exercise. In all, the pre-exercise consumption of the two antihistamines reduced the blood flow that occurs during recovery by 80 percent.
The study, funded by the American Heart Association, was posted online ahead of regular publication in the Journal of Applied Physiology. While fainting after exercise, a condition called syncope, can indicate a serious heart disorder, most cases are linked to low blood pressure and low blood flow to the brain.
The older antihistaminic agent terfenadine was found to metabolize into the related carboxylic acid, fexofenadine. Fexofenadine was found to retain all of the biological activity of its parent while giving fewer adverse reactions in patients, so terfenadine was replaced in the market by its metabolite.[5] Fexofenadine was originally synthesized in 1993 by Massachusetts-based biotechnology company Sepracor, which then sold the development rights to Hoechst Marion Roussel (now part of Sanofi-Aventis), and was later approved by the Food and Drug Administration (FDA) in 1996. AMRI holds the patents to the intermediates and production of fexofenadine HCl along with Roussel. Since that time, it has achieved blockbuster drug status with global sales of $1.87B USD in 2004 (with $1.49B USD coming from the United States). AMRI received royalty payments from Aventis that enabled the growth of AMRI.
1.
Positive Aspects of Allegra:
It worked within 24 hrs.
Negative Aspects of Allegra:
minor headache
Reason for taking Allegra:
Allergies
Additional Comments:
This medication really help me reduce my seasonal allergies and relieve my built up congestion.
2.
Positive Aspects of Allegra:
12 hr release works within 1 hr
Negative Aspects of Allegra:
lots of back pain
Reason for taking Allegra:
seasonal allergies
Additional Comments:
The 12hr release works better for me. The 24hr passes through my system without dissolving. Maybe too much coating, not sure.
3.
Positive Aspects of Allegra:
Stops my allergies majority of the time
Negative Aspects of Allegra:
none
Reason for taking Allegra:
year round allergies
Additional Comments:
Allegra has been a blessing in my life. I have been tested by an allergist and it seems like I am allergic to almost everything. About three years ago, the MD suggested that I just take Allegra year-round and except for the beginning of spring and fall, my allergies are under control. The best part is no drowsiness.
Let’s say that you are allergic to the perfume in a lotion, but you get
some on your skin by accident. You break out in an itchy rash where
the lotion touched your skin.
What is happening is that the perfume in the lotion caused the cells in
your body to release histamine. The histamine gets onto the surface
of your skin cells and causes an itchy rash. What do you do?
You take a dose of antihistamine such as Benadryl (diphenhydramine)
or Allegra (fexofenidine). The antihistamine acts like a bouncer. It kicks
the histamine off of the skin cells and prevents the histamine from
reacting to cause inflammation, redness and itch.
Within minutes the rash should subside and the itching go away.
Important Information
Both the drugs Allegra and Telfast are one and the same. The manufacturer Sanofi Aventis sells the same medication but under different names; Allegra in the US and Telfast in the UK.
Allegra dosage
The normal dosage of Allegra or Telfast is one tablet twice a day with the strength to be decided by your doctor.
You should take it with a full glass of water or as directed by your doctor. You can take this medicine with or without food.
If Allegra does not relieve your symptoms, do not take extra tablets. Tell your doctor or pharmacist about it. Taking more dose than recommended does not mean faster and better results. It is not advisable to take extra dose as it will only increase the chances of side effects.
Allegra should not be taken by children below the age of 12 years as there is currently insufficient information available about its safety in this age group.
Side effects of Allegra
Side effects of Allegra or Telfast are headache, tiredness, nausea and indigestion. These same effects were seen in patients taking placebo treatment during clinical studies.
Allegra/Telfast precautions
Do not take Allegra or Telfast if you have had an allergic reaction to fexofenadine terfenadine (Teldane) or any of the other ingredients in Allegra. Please tell your doctor about all your allergies before taking Allegra.
Seasonal allergic rhinitis is an acute condition. You should seek the advice of your doctor or pharmacist if you need more than 14 days of continuous Allegra treatment.
In addition, to the active ingredient in Allegra, Fexofenadine HCL, Allegra D also contains pseudoephedrine HCl. Pseudoephedrine HCl is an orally active sympathomimetic amine and exerts a decongestant action on the nasal mucosa. Pseudoephedrine HCl is recognized as an effective agent for the relief of nasal congestion due to allergic rhinitis.
There is sometimes an immediate connection between the immune system of the body and the stress that we undergo. The more the stress, the weaker the immunity. Some of us develop certain allergies over time and the stress makes it worse. With little time left to ourselves, we are left with no option, but medication. The news is that Allegra, scientifically known as Fexofenadine hydrochloride is an effective drug developed for treating hay fever and other allergic symptoms. A very imperative question that immediately arises is if it is as fatal as an earlier version, referred to as terfenadine. We can all rest assured in the case of Allegra, however, because unlike it’s predecessor, Allegra does not enter the brain directly through blood, and is hence, less fatal and far more safer, hence effective. Who would want to get new allergies for old ones in any case?
Some may not know much about this, but Allegra is an antihistamine drug of the second generation. Antihistamines work against the naturally occurring chemical histamine in your body. Besides on hay fever, it works well against a runny nose, watery and itchy eyes also. However, it is important to consult your physician against any serious illness that you might have or a dosage adjustment, if required. Some of the likely allegra side effects are as follows: difficulty in breathing, closing of the throat, swelling of the lips, tongue or face, nausea, upset stomach etc. It has also been touted as a strict no-no for pregnant women.
Often a variety of choices is more confusing that helpful, but the important thing to remember is that this one has been developed after a whole generation of antihistamines and is more or less proven. Find your most trusted online pharmacy, not necessarily the cheapest, and you’re all set to buy Allegra. There are more ways than one to deal with allergies.
ALLEGRA
Adults and Children 12 Years and Older
For hay fever, the usual dosage is 60 milligrams twice a day or 180 milligrams once a day. For hives, it’s 60 milligrams twice a day. If you have kidney problems, your doctor may have you take only one 60-milligram dose daily.
Children 6 through 11 years old
For hay fever or hives, the usual dosage is 30 milligrams twice a day. Children with kidney problems may be prescribed only one 30-milligram dose each day.
ALLEGRA-D
Adults and Children 12 Years and Older
12-Hour Tablets: Take 1 tablet twice a day. People with kidney problems should take only 1 tablet daily.
24-Hour Tablets: Take 1 tablet once a day. Allegra-D 24-hour tablets should generally not be taken by people with kidney problems.
Allegra-D is not recommended for children less than 12 years old.